We learned from the passing of our son Liam James that we were both carriers for a genetic
disorder called GACI (Generalised Infantile Arterial Calcification) [AKA] IACI
(Idiopathic Arterial Calcification of Infancy). His autopsy showed signs of the
disorder. His DNA was observed and the mutation in his genes was found. My self
and my husband were tested and confirmed we were both in fact unaffected
carriers. This means we do not have the disorder, but we have the ability to
pass it down to our children. We have a 25% chance of having an affected
carrier with each pregnancy. This was the case with Liam. This was also the
case with our 2015 pregnancy. This could have also been the cause of my two
miscarriages although we will never know for sure and it could never be
proven.
After so much loss and failed attempts, we chose to pursue IVF w/PGD to
grow our family. This means we will use in vitro fertilization (IVF) and
Pre-implantation genetic diagnosis. A normal round of IVF consists of
monitoring and stimulating a woman's ovulatory process, retrieving eggs from
the the woman's ovaries and letting sperm fertilise them at a laboratory. The
fertilised eggs move forward to mature. Then they are implanted the woman's
uterus, with the intention of establishing a successful pregnancy. Adding PGD
to this means that after the eggs are fertilized and mature they undergo
genetic testing before implantation. Only the embryos that appear strong and
are cleared of our genetic disorder are moved forward to consider using for
implantation.
Obviously, for situations like ours, this is a miracle in itself. To have the
science and knowledge to prevent this type of suffering is truly miraculous.
Internet research (the same type of research that could convince you that your
common head cold is a fatal catastrophe) indicated that success rates with PGD
increased your chances with IVF. Most miscarriages are loosely links to
chromosome and genetic abnormalities that we have no control over. Adding this
extra step to examine the embryos before implantation reduces these risks. I
could talk about statistics since I've spent DAYS researching them, but, the
flat our answer is that there are too many factors to give a blanket success
rate. Your Fertility Clinic will give you their best guestimate once you've
begun the process and they know your details specifically.
I had heard that the process is expensive. I saw quotes from $10,000.00 -
$30,000.00 for both IVF and PGD together. Again, I was swimming around in
internet articles and my own assumptions weighed down by my fears. It wasn't
until I went to the Fertility Center, that I finally got the information that I
was looking for.
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